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KMID : 1147520210140020103
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Korean Academy of Basic Medicine & Health Science
2021 Volume.14 No. 2 p.103 ~ p.107
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Zerumbone’s Effects on Mouse Spleen T Cell Migration and Proliferation
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Moon Cheol
Kim Si-Hyun
Choi Hwa-Sik
Yu Sung-Ryul
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Abstract
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Zerumbone is the main ingredient extracted from wild ginger Zingiber zermbet Smith. It is known that the root of ginger contains the most zerumbone. It has been reported to function in several biological environments, including tumors and inflammation. In addition, it is known to affect the functions of several types of cells, including immune cells. In this study, it was confirmed that the migration phenomenon induced by SDF-1α was inhibited by zerumbone using T cells isolated from mouse spleen. On the other hand, the proliferation of mouse T cells through antiCD3 and anti-CD28 antibodies was not affected by zerumbone. Zerumbone inhibited phosphorylation of Erk1/2 signaling protein induced by SDF1α. This result has the meaning of confir ming that the effect of zerumbone confirmed in T cell lines also occurs in physiological T cells, and more detailed biochemical and cytological mechanisms are needed.
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KEYWORD
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Migration, Proliferation, T lymphocyte, Zerumbone
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